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KMID : 0358419820250080975
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Korean Journal of Obstetrics and Gynecology
1982 Volume.25 No. 8 p.975 ~ p.985
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Bata-Human Chorionic Gonadotropin Titration on Ectopic Pregnancies
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M.L.Park
H. Moon/D.S. Kim
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Abstract
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Since the morbidity and mortality associated with ectopic pregnancy are related in part to the length of time between onset of symptoms and surgery, the early diagnosis has been emphasized for minimizing untoward sequele following delayed diagnosis. Among the methods used to diagnose ectopic pregnancy the immunologic prgnancy test of the urine, sensitive to 600-700IU of hCG per liter, is positive only between 50.0 and 87.5%. The sensitivity of radioreceptor assay for hCG varies from 5 to 200mIU/ml of serum according to the methods and the rates of false negative result have been reported to be 0 to 10%. A great advance in the early diagnosis of ectopic pregnancy has been made with the development of beta-submit titration of hCG by radioimmunoassay which is capale of measuring as little as 5 mIU/ml of serum in the presence of physiologic concentrations of LH. The drawback of the long incubation period has been overcome by a rapid modification reducing to 2-3 hours without loss of specificity, sensitivity, or precision. Recently the increased reliability of beta-hCG titration by RIA over the widely used urinary pregnancy test and hCG radioreceptor assay has been previously documented. Schwartz stated that in patients with suspected ectopic pregnancy, a negative beta-hCG by the RIA technique ruled out ectopic pregnancy in 100% of the cases. However, 2 cases of false negative results have been reported in the literatures, one by Khoo and the other by Kauppila. The reported clinical accuracy of the beta-hCG measurement varies between 97 and 100%. This study was undertaken to confirm the clinical significance of measurement of serum beta-hCG by RIA in the early diagnosis of ectopic pregnancy and to discuss its false negative incidence and the previous different observations and explanations concerning the difference of beta-hCG values between the ruptured and the unruptured.
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KEYWORD
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